Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 1.965


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA7hg19_v1_chr7_-_27196163_27196328-0.226.7e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_18535351 7.896 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chrM_+_10123 6.952


chr7_+_28452143 6.146 NM_182898
CREB5
cAMP responsive element binding protein 5
chr10_-_92681025 4.108 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_184243578 3.915 NM_001185149
CLDN24
claudin 24
chr3_-_114478117 3.896 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr15_+_71839540 3.786 THSD4
thrombospondin, type I, domain containing 4
chr1_+_168250277 3.707 NM_005149
TBX19
T-box 19
chr4_+_71494460 3.675 NM_031889
ENAM
enamelin
chr1_+_167298382 3.602 POU2F1
POU class 2 homeobox 1
chrX_-_124097601 3.291 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr2_-_145277568 3.261 ZEB2
zinc finger E-box binding homeobox 2
chr7_+_28475233 3.160 NM_004904
CREB5
cAMP responsive element binding protein 5
chr1_+_167298280 3.157 NM_001198783
POU2F1
POU class 2 homeobox 1
chr8_-_42234562 3.129 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr13_+_36050885 3.100 NM_001204197
NBEA
neurobeachin
chr7_+_18330044 3.081 HDAC9
histone deacetylase 9
chr2_-_145277879 3.045 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr4_+_108814419 3.019 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr10_-_32667543 2.902 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr17_-_39092714 2.885 KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_168545710 2.775 NM_002995
XCL1
chemokine (C motif) ligand 1
chr6_-_76203256 2.773 NM_015687
FILIP1
filamin A interacting protein 1
chr3_-_114790221 2.770 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_18535817 2.701 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr16_+_69680959 2.581 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr15_+_93443559 2.480 CHD2
chromodomain helicase DNA binding protein 2
chr15_+_93443418 2.433 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr10_-_92680784 2.429 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_-_39093671 2.356 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr9_+_12693385 2.296 NM_000550
TYRP1
tyrosinase-related protein 1
chr6_+_149721494 2.294 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr2_+_210444364 2.277 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr7_+_107110501 2.254 NM_005295
GPR22
G protein-coupled receptor 22
chr1_+_177140062 2.236 FAM5B
family with sequence similarity 5, member B
chr3_-_101039403 2.236 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr8_-_6420454 2.206 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr4_-_83347778 2.187 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr19_+_13134782 2.182 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_-_129062092 2.117 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr6_-_53013581 2.074 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr2_-_233641225 2.007 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr10_+_126630691 1.979 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr2_-_161130151 1.964 RBMS1
RNA binding motif, single stranded interacting protein 1
chr12_-_53901371 1.952 NM_003717
NPFF
neuropeptide FF-amide peptide precursor
chr2_+_171571800 1.925 NM_001003845
SP5
Sp5 transcription factor
chr3_+_88188261 1.911 NM_018293
ZNF654
zinc finger protein 654
chr1_+_212782103 1.855 ATF3
activating transcription factor 3
chr1_-_193155723 1.840 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr5_+_137673223 1.823 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr7_-_27166638 1.817 NM_153631
HOXA3
homeobox A3
chr15_+_100173182 1.815 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr14_-_57960432 1.815 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr3_-_187452669 1.812 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr1_+_212781969 1.789 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr12_+_119616594 1.758 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_+_28410132 1.755 NM_018318
CCDC91
coiled-coil domain containing 91
chr3_-_114343052 1.739 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_29038862 1.734 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr1_-_27732069 1.722 WASF2
WAS protein family, member 2
chr3_+_63953419 1.719 NM_001128149
ATXN7
ataxin 7
chr9_-_5968367 1.714


chr13_+_97874704 1.674 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_112120907 1.657 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr7_+_28725597 1.605 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr5_+_59784004 1.599 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr7_+_28448970 1.596 LOC401317
uncharacterized LOC401317
chr18_+_32173281 1.588 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr12_-_28124915 1.579 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr18_+_32290195 1.575 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr12_-_15865847 1.565 EPS8
epidermal growth factor receptor pathway substrate 8
chr10_-_65028825 1.563 NM_004241
JMJD1C
jumonji domain containing 1C
chr2_+_210444154 1.563 MAP2
microtubule-associated protein 2
chr12_-_53994783 1.535 NM_001130059
ATF7
activating transcription factor 7
chr19_+_45971249 1.515 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chrX_+_70765479 1.497 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr10_-_77161136 1.496 ZNF503
zinc finger protein 503
chr2_+_171571936 1.487


chr21_-_33074101 1.478 SCAF4
SR-related CTD-associated factor 4
chr13_-_60325073 1.459


chr3_+_128532267 1.456


chr13_+_24144402 1.455 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr5_-_39394423 1.440 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_-_83984230 1.430 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr3_+_63884074 1.408 NM_001177387
ATXN7
ataxin 7
chr4_+_74606222 1.404 NM_000584
IL8
interleukin 8
chr7_+_39017608 1.400 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr7_-_41742666 1.392 NM_002192
INHBA
inhibin, beta A
chr18_+_32073245 1.392 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr4_+_88571453 1.392 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr10_-_77161424 1.374 NM_032772
ZNF503
zinc finger protein 503
chr1_+_46379258 1.373 MAST2
microtubule associated serine/threonine kinase 2
chr17_-_49124128 1.345 NM_001251971
SPAG9
sperm associated antigen 9
chr15_+_57511616 1.344 NM_207040
TCF12
transcription factor 12
chr3_+_157154579 1.341 NM_002852
PTX3
pentraxin 3, long
chr8_+_32579350 1.334 NM_001159996
NRG1
neuregulin 1
chr3_-_114102488 1.310 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr17_-_8063946 1.308 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr8_+_92261515 1.286 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr3_-_87325611 1.276 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr4_+_160188997 1.276 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_-_47933997 1.271 MAP4
microtubule-associated protein 4
chrM_+_10361 1.268


chr3_+_156394452 1.267 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr9_+_2717525 1.256 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr5_-_124080773 1.255 NM_020747
ZNF608
zinc finger protein 608
chr2_-_211018294 1.247 C2orf67
chromosome 2 open reading frame 67
chr3_+_115342302 1.238 GAP43
growth associated protein 43
chr1_-_94586678 1.230 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr1_-_100643770 1.226 NM_144620
LRRC39
leucine rich repeat containing 39
chr22_-_38506532 1.221 BAIAP2L2
BAI1-associated protein 2-like 2
chrM_+_1670 1.220


chr14_+_55168831 1.219 SAMD4A
sterile alpha motif domain containing 4A
chr12_+_50869531 1.217 LARP4
La ribonucleoprotein domain family, member 4
chr11_-_84634437 1.206 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_56716713 1.206 DST
dystonin
chr3_+_141043054 1.203 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr18_+_32073343 1.202 DTNA
dystrobrevin, alpha
chr1_+_151739130 1.192 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr11_-_84634219 1.186 DLG2
discs, large homolog 2 (Drosophila)
chr15_-_70390229 1.179 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr3_+_151488214 1.170 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chrM_+_2211 1.169


chr10_-_77161539 1.159 ZNF503
zinc finger protein 503
chr9_+_103340335 1.154 NM_001018116
MURC
muscle-related coiled-coil protein
chr3_+_25470067 1.146 RARB
retinoic acid receptor, beta
chrM_+_10704 1.135


chr10_-_75335415 1.132 NM_152586
USP54
ubiquitin specific peptidase 54
chr15_-_70390226 1.123 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr13_+_97928414 1.120 MBNL2
muscleblind-like 2 (Drosophila)
chr12_-_99548867 1.108 NM_001204067
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr20_+_32150139 1.106 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr4_-_74088773 1.104 ANKRD17
ankyrin repeat domain 17
chr11_+_124481451 1.097 NM_052959
PANX3
pannexin 3
chr7_-_27205075 1.086 HOXA9
homeobox A9
chr6_-_149806116 1.082 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr4_+_74286846 1.070 ALB
albumin
chr2_+_33359607 1.066 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr6_+_87964925 1.059 ZNF292
zinc finger protein 292
chr2_-_133539627 1.057 NCKAP5
NCK-associated protein 5
chr10_-_14372807 1.049 NM_018027
FRMD4A
FERM domain containing 4A
chr22_+_39101954 1.047 GTPBP1
GTP binding protein 1
chr4_-_153273683 1.047 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr12_-_71031174 1.038 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr7_-_16505292 1.038 NM_015464
SOSTDC1
sclerostin domain containing 1
chr13_-_41593491 1.033 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_63009302 1.033 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chrM_+_11427 1.031


chr6_+_7579692 1.017 DSP
desmoplakin
chr6_-_138189313 1.013


chr7_-_155601757 1.011 SHH
sonic hedgehog
chr4_+_118955499 1.001 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr7_-_44580857 1.000 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr13_-_41556188 0.996 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_97874540 0.993 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr6_-_56507585 0.983 NM_001723
NM_015548
DST

dystonin

chr7_-_37025696 0.982 ELMO1
engulfment and cell motility 1
chr10_+_63808968 0.981 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_117319231 0.980 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr14_-_81864726 0.970 NM_033104
STON2
stonin 2
chr1_+_167189948 0.967 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr20_-_55934877 0.964 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr8_+_77593522 0.962 ZFHX4
zinc finger homeobox 4
chr19_+_13135368 0.957 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_105421044 0.953 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr6_-_41703938 0.953 NM_001167827
TFEB
transcription factor EB
chr13_-_41593405 0.951 ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_-_83393436 0.941 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr11_-_85338313 0.941 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr13_+_78315294 0.940 NM_001242869
NM_001242870
NM_001242871
NM_144595
SLAIN1



SLAIN motif family, member 1



chrX_+_69488154 0.938 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr4_-_82393025 0.934 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chrX_-_76814217 0.929 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr7_+_116395440 0.926


chr12_-_26277807 0.925 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr10_+_63661012 0.923 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr5_-_39424930 0.922 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_-_46651809 0.919 NM_002146
HOXB3
homeobox B3
chr9_-_110251308 0.919 KLF4
Kruppel-like factor 4 (gut)
chr4_-_82392971 0.917 RASGEF1B
RasGEF domain family, member 1B
chr10_-_62149487 0.917 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_198540583 0.913 NM_144629
RFTN2
raftlin family member 2
chr12_-_102874373 0.912 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr14_+_75745480 0.910 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr1_-_213020947 0.909 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr8_+_77593506 0.906 NM_024721
ZFHX4
zinc finger homeobox 4
chrM_+_14601 0.903


chr10_-_126716452 0.899 NM_022802
CTBP2
C-terminal binding protein 2
chr7_+_102553343 0.896 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr6_-_56716412 0.895 DST
dystonin
chr4_+_88529680 0.895 NM_014208
DSPP
dentin sialophosphoprotein
chr1_+_78470593 0.894 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_-_51611476 0.894 POU6F1
POU class 6 homeobox 1
chr18_+_3447607 0.890 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr16_+_69984809 0.890 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr3_-_25683825 0.886 TOP2B
topoisomerase (DNA) II beta 180kDa
chr6_-_53530505 0.880 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr8_-_87755880 0.868 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr7_-_87342569 0.866 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr2_+_54785453 0.865 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.75 3.26e-06 GO:0050794 regulation of cellular process
2.58 2.02e-05 GO:0010556 regulation of macromolecule biosynthetic process
2.68 2.44e-05 GO:0051252 regulation of RNA metabolic process
2.70 3.45e-05 GO:0006355 regulation of transcription, DNA-dependent
2.58 3.59e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.47 4.00e-05 GO:0031326 regulation of cellular biosynthetic process
1.65 5.12e-05 GO:0050789 regulation of biological process
2.44 5.38e-05 GO:0009889 regulation of biosynthetic process
2.40 8.79e-05 GO:0051171 regulation of nitrogen compound metabolic process
2.40 1.32e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.14 1.37e-04 GO:0031323 regulation of cellular metabolic process
2.44 1.46e-04 GO:0010468 regulation of gene expression
2.18 1.89e-04 GO:0060255 regulation of macromolecule metabolic process
2.12 2.75e-04 GO:0080090 regulation of primary metabolic process
1.55 9.55e-04 GO:0065007 biological regulation
1.94 2.12e-03 GO:0019222 regulation of metabolic process
2.32 9.47e-03 GO:0048523 negative regulation of cellular process
6.26 2.81e-02 GO:0048514 blood vessel morphogenesis
1.84 3.13e-02 GO:0032502 developmental process
12.26 3.55e-02 GO:0051147 regulation of muscle cell differentiation
7.11 3.85e-02 GO:0001525 angiogenesis
4.17 4.35e-02 GO:0048646 anatomical structure formation involved in morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.58 1.13e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.78 6.58e-06 GO:0001071 nucleic acid binding transcription factor activity
3.78 6.58e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
3.73 1.35e-03 GO:0043565 sequence-specific DNA binding
2.13 5.96e-03 GO:0003677 DNA binding
1.86 9.98e-03 GO:0003676 nucleic acid binding